Eight Misbehavin': Season 11, Episode 7

"They're a ravenous swarm of locusts, just eating and screaming and grabbing and poking and pulling and drooling...and two have cradle rash.  How do you get cradle rash when you sleep in a suitcase?"

--Apu

This episode reveals the consequences of fertility drugs.  Apu and Manjula Nahasapeemapetilon are frustrated because they have been unable to conceive a child.  Despite Homer's moronic (but well intentioned) attempts at assisting them, the Simpsons and the Nahasapeemapetilons eventually turn to fertility drugs.  Manjula secretly takes these drugs, Apu slips them into her breakfast squishy, and Marge, Bart, and Homer also slip Manjula fertility drugs.  According to Homer, his drugs tasted like strawberry.  He refers to them as, "ovulicous."  This large dosage of fertility drugs results in multiple births, and the Nahasapeemapetilons end up having eight children.  

Homer, who is overwhelmed at merely the thought of eight kids, exchanges this dialogue with Marge:

Homer: "I'm sterile, right baby doll?"

Marge: "Yes dear, from the nuclear plant."

Homer: "Beautiful."

Initially, everything goes great for the Nahasapeemapetilons.  The children are a huge media hit, and the the family is showered with gifts and support from many corporate companies.  However, when a mother in Shelbyville gives birth to 9 babies, the attention and products are whisked away from the Nahasapeemapetilons and given to the Shelbyville mother.  

Apu and Manjula struggle to keep their heads above water.  All eight children develop colic, making the situation even more difficult for their parents.  Apu and Manjula are overtired, overwhelmed, and inadequately prepared for this many newborns. 

Eventually, Apu ends up agreeing to exhibiting his octuplets in a zoo.  In the end, however, he and Homer steal them back.  After they are caught, Homer decides to offer himself up for the cause.  Instead of giving the babies back to the zoo (due to the contract that Apu and Manjula had previously signed), Homer agrees to ride around on a tricycle while holding Butch Patrick on his back and being bitten by cobras simultaneously.  This act will make up for the loss of the octuplets as a zoo attraction.  Apu notes that Homer is quite a good friend.